group

IN GENERAL,

we study biomolecules and their interactions by biophysical and bioinformatic tools. We focus on interactions driving specific recognition between biomolecules with potential diagnostic, medical or biotechnological use.

At the molecular level, the essence of the biological processes consists in interactions between biomolecules. Our goal is to understand mechanisms of their mutual recognition proteins and nucleic acid specific. We concentrate on determination of molecular structure and dynamics, study specific protein-protein and protein-DNA interactions. We take advantage of experimental and computational methods of protein engineering, structural biology and bioinformatics, and molecular modeling.

You can see the short video about our group

PROJECTS RUNNING IN THE LABORATORY

5eh1

Cytokines

We study structure-function relationships of medically important signaling proteins crucial in immune response, cytokines. We study their structures and interactions and also try to modulate their function by developing de novo small protein binders.

bioinformatics

Bioinformatics

Our lab concentrates on structural analysis of nucleic acids, DNA and RNA, and of solvation around proteins and nucleic acids. Our bioinformatic research is based on original approaches and we develop our own analytical tools. The results are available on the website structbio.org.

ssDNA

Single stranded DNA

Single stranded DNA (ssDNA) are known to play important yet largely unknown functions in the genome regulation. We study one specific class of bacterial ssDNA, so called Repetitive extragenic palindromes (REP) and their associated enzyme, tyrosine transposase (RAYT).

dynamics

Dynamics of Biomolecules - ELIBIO Project

in collaboration with the ELI Beamlines research center

We explore new frontiers in light and optics to create breakthrough science about biomolecular dynamics at very high time resolution.

cooperations

COOPERATIONS

The lab is a part of IBT, located at the BIOCEV center, and actively participates at ELIXIR and Instruct-ERIC infrastructural projects.